Miniature Synaptic Currents Become Neurotoxic to Chronically Silenced Neurons
نویسندگان
چکیده
منابع مشابه
Miniature synaptic currents become neurotoxic to chronically silenced neurons.
When deprived of spontaneous ongoing network activity by chronic exposure to tetrodotoxin (TTX), cultured cortical neurons retract their dendrites, lose dendritic spines, and degenerate over a period of 1-2 weeks. Electrophysiological properties of these slowly degenerating neurons prior to their death are normal, but they express very large miniature excitatory postsynaptic currents (mEPSCs). ...
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Maintenance of a low intraneuronal Cl- concentration, [Cl-]i, is critical for inhibition in the CNS. Here, the contribution of passive, conductive Cl- flux to recovery of [Cl-]i after a high load was analyzed in mature central neurons from rat. A novel method for quantifying the resting Cl- conductance, important for [Cl-]i recovery, was developed and the possible contribution of GABAA and glyc...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2006
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhl037